| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amtB | arfM | BSU36510 | BSU37290 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ. | 0.448 |
| amtB | fnr | BSU36510 | BSU37310 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | 0.733 |
| amtB | glnA | BSU36510 | BSU17460 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | 0.958 |
| amtB | glnK | BSU36510 | BSU36520 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | 0.999 |
| amtB | gltA | BSU36510 | BSU18450 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.846 |
| amtB | nasA | BSU36510 | BSU03330 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Putative nitrate transporter; May function as a nitrate transporter. | 0.917 |
| amtB | nasE | BSU36510 | BSU03290 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. Required for activity of the reductase (By similarity). | 0.651 |
| arfM | amtB | BSU37290 | BSU36510 | Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ. | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | 0.448 |
| arfM | fnr | BSU37290 | BSU37310 | Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ. | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | 0.808 |
| arfM | glnK | BSU37290 | BSU36520 | Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ. | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | 0.569 |
| arfM | gltA | BSU37290 | BSU18450 | Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ. | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.410 |
| argB | glnK | BSU11210 | BSU36520 | N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | 0.903 |
| argB | gltA | BSU11210 | BSU18450 | N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.536 |
| fnr | amtB | BSU37310 | BSU36510 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | 0.733 |
| fnr | arfM | BSU37310 | BSU37290 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ. | 0.808 |
| fnr | glnK | BSU37310 | BSU36520 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | 0.906 |
| fnr | gltA | BSU37310 | BSU18450 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.410 |
| fnr | nasA | BSU37310 | BSU03330 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Putative nitrate transporter; May function as a nitrate transporter. | 0.569 |
| fnr | nasE | BSU37310 | BSU03290 | Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration. | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. Required for activity of the reductase (By similarity). | 0.721 |
| glnA | amtB | BSU17460 | BSU36510 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | 0.958 |