node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
comA | phrF | BSU31680 | BSU37470 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | 0.483 |
comA | rapF | BSU31680 | BSU37460 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.998 |
comA | srfAA | BSU31680 | BSU03480 | Two-component response regulator; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. | Surfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. | 0.432 |
phrA | phrC | BSU12440 | BSU03780 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | 0.917 |
phrA | phrE | BSU12440 | BSU25840 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Regulator of the activity of phosphatase RapE; Inhibitor of the activity of phosphatase RapE. | 0.923 |
phrA | phrF | BSU12440 | BSU37470 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | 0.776 |
phrA | phrG | BSU12440 | BSU40310 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Secreted regulator of the activity of phosphatase RapG; Inhibitor of the activity of phosphatase RapG. | 0.637 |
phrA | phrH | BSU12440 | BSU06839 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Hexapeptide inhibitor of regulatory cascade; Inhibitor of the activity of phosphatase RapH. May inhibit the rapH promoter after import into the cytoplasm. | 0.825 |
phrA | phrK | BSU12440 | BSU18920 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Secreted regulator of the activity of phosphatase RapK; Inhibitor of the activity of phosphatase RapK. | 0.760 |
phrA | rapF | BSU12440 | BSU37460 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.758 |
phrA | spo0F | BSU12440 | BSU37130 | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.921 |
phrC | phrA | BSU03780 | BSU12440 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted inhibitor of the activity of phosphatase RapA; Inhibitor of the activity of phosphatase RapA. | 0.917 |
phrC | phrE | BSU03780 | BSU25840 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Regulator of the activity of phosphatase RapE; Inhibitor of the activity of phosphatase RapE. | 0.871 |
phrC | phrF | BSU03780 | BSU37470 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted regulator of the activity of phosphatase RapF; Inhibitor of the activity of phosphatase RapF; Belongs to the phr family. | 0.941 |
phrC | phrG | BSU03780 | BSU40310 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted regulator of the activity of phosphatase RapG; Inhibitor of the activity of phosphatase RapG. | 0.726 |
phrC | phrH | BSU03780 | BSU06839 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Hexapeptide inhibitor of regulatory cascade; Inhibitor of the activity of phosphatase RapH. May inhibit the rapH promoter after import into the cytoplasm. | 0.630 |
phrC | phrK | BSU03780 | BSU18920 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Secreted regulator of the activity of phosphatase RapK; Inhibitor of the activity of phosphatase RapK. | 0.849 |
phrC | rapF | BSU03780 | BSU37460 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Response regulator aspartate phosphatase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.941 |
phrC | spo0F | BSU03780 | BSU37130 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Two-component response regulator; Key element in the phosphorelay regulating sporulation initiation. Phosphorylation of spo0B during sporulation initiation. | 0.712 |
phrC | srfAA | BSU03780 | BSU03480 | Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family. | Surfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. | 0.840 |