Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bacH | cysL | BSU37680 | BSU37650 | Cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis; Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP). Although the [...] | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | 0.475 |
| bacH | hemQ | BSU37680 | BSU37670 | Cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis; Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP). Although the [...] | Essential component of heme biosynthesis; May function as heme-dependent peroxidase. | 0.833 |
| bacH | lipL | BSU37680 | BSU37640 | Cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis; Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP). Although the [...] | Octanoyl-[GcvH]:protein N-octanoyltransferase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. | 0.477 |
| cymR | cysL | BSU27520 | BSU37650 | Transcriptional regulator of cysteine biosynthesis; Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the Cy [...] | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | 0.752 |
| cysH | cysJ | BSU15570 | BSU33440 | (phospho)adenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Sulfite reductase (flavoprotein alpha-subunit); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component (Probable). | 0.998 |
| cysH | cysL | BSU15570 | BSU37650 | (phospho)adenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | 0.499 |
| cysJ | cysH | BSU33440 | BSU15570 | Sulfite reductase (flavoprotein alpha-subunit); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component (Probable). | (phospho)adenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.998 |
| cysJ | cysL | BSU33440 | BSU37650 | Sulfite reductase (flavoprotein alpha-subunit); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component (Probable). | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | 0.504 |
| cysL | bacH | BSU37650 | BSU37680 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis; Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP). Although the [...] | 0.475 |
| cysL | cymR | BSU37650 | BSU27520 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Transcriptional regulator of cysteine biosynthesis; Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the Cy [...] | 0.752 |
| cysL | cysH | BSU37650 | BSU15570 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | (phospho)adenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.499 |
| cysL | cysJ | BSU37650 | BSU33440 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Sulfite reductase (flavoprotein alpha-subunit); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component (Probable). | 0.504 |
| cysL | hemQ | BSU37650 | BSU37670 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Essential component of heme biosynthesis; May function as heme-dependent peroxidase. | 0.489 |
| cysL | lipL | BSU37650 | BSU37640 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Octanoyl-[GcvH]:protein N-octanoyltransferase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. | 0.929 |
| cysL | pta | BSU37650 | BSU37660 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Phosphotransacetylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.536 |
| cysL | resD | BSU37650 | BSU23120 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. | 0.468 |
| cysL | ywdK | BSU37650 | BSU37930 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0382 family. | 0.568 |
| cysL | ywfM | BSU37650 | BSU37630 | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | Putative transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter. | 0.761 |
| hemQ | bacH | BSU37670 | BSU37680 | Essential component of heme biosynthesis; May function as heme-dependent peroxidase. | Cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis; Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP). Although the [...] | 0.833 |
| hemQ | cysL | BSU37670 | BSU37650 | Essential component of heme biosynthesis; May function as heme-dependent peroxidase. | Regulator of sulfur assimilation CysL, activates cysJI expression; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription. | 0.489 |
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