STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ywcCUncharacterized HTH-type transcriptional regulator YwcC; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator (223 aa)    
Predicted Functional Partners:
slrA
Transcriptional regulator slra; Required specifically for induction of eps and yqxM operons by antagonizing SinR. Regulates SlrR activity. Controls the initiation of biofilm formation
     
 0.950
sinI
Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE
      
 0.901
sinR
Xre family transcriptional regulator, master regulator for biofilm formation; Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swa [...]
      
 0.900
epsA
Uncharacterized protein YveK; Evidence 2b: Function of strongly homologous gene; Product type r : regulator
  
   
 0.899
tapA
Lipoprotein for biofilm formation; Required for biofilm formation Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface . Is also a minor component of TasA fibers
      
 0.889
sipW
Type i signal peptidase; Required for the cleavage of the signal sequence of TasA and TapA, which are involved in biofilm formation
      
 0.880
slrR
Hth-type transcriptional regulator, biofilm formation regulator; Represses sigma(D)-dependent flagellar genes and activate the eps and yqxM operons. Repressor activity is regulated by SlrA. Controls the initiation of biofilm formation
  
   
 0.812
ywcD
Uncharacterized membrane protein YwcD; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component
       0.806
galT
Galactose-1-phosphate uridylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme
     
 0.760
gutR
Luxr family transcriptional regulator, glucitol operon activator; Activator of the glucitol dehydrogenase gene (gutB)
  
     0.755
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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