STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sacXSucrose pts system eiibca or eiibc component; Negatively regulates SacY activity by catalyzing its phosphorylation on 'His-99'. Negatively regulates SacY (459 aa)    
Predicted Functional Partners:
sacY
Levansucrase and sucrase synthesis operon antiterminator; In the presence of sucrose, SacY is activated and prevents premature termination of transcription by binding to a RNA- antiterminator (RAT) sequence (partially overlapping with the terminator sequence) located upstream of the sacB gene. Formation of the SacY-RAT complex prevents alternative formation of the terminator, allowing transcription of the sacB gene. In the absence of sucrose, inhibition of SacY activity by SacX leads to termination of transcription
 
 
 
 0.995
sacA
sucrase-6-phosphate hydrolase; Belongs to the glycosyl hydrolase 32 family
  
 0.986
sacT
Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription
 
 
 
 0.968
ypqE
Putative phosphotransferase system enzyme iia component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
 
 0.953
ptsG
Phosphotransferase system (pts) glucose-specific enzyme iicba component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport
 
 0.938
sacB
Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme
 
   
 0.937
gamP
Phosphotransferase system (pts) glucosamine-specific enzyme iicba component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system may be involved in glucosamine transport
 
 0.933
yyzE
Putative phosphotransferase system enzyme iia component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
 
 0.921
ptsH
Histidine-containing phosphocarrier protein of the phosphotransferase system (pts) (hpr protein); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain
  
 0.897
ywdA
Hypothetical protein; Uncharacterized protein YwdA; Evidence 5: No homology to any previously reported sequences
      
 0.889
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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