STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtbDRibonuclease toxin of the RtbD-RtbE toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 409-569) has RNase activity, and inhibits growth upon expression in E.coli. In vitro RNase activity and in vivo growth inhibition are neutralized by cognate antitoxin YxxD, but not by antitoxins specific to other toxins with the LXG domain. (569 aa)    
Predicted Functional Partners:
rtbE
Antitoxin factor of the RttD-RttE toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the RNase activity of cognate toxin YxiD, as well as its ability to inhibit growth upon expression in E.coli. Does not have antitoxin activity on other toxins with the LXG toxin domain.
  
  
 0.986
yxiC
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.986
yxxE
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.939
rttN
Putative ribonuclease toxin; Probable toxic component of a type II toxin-antitoxin (TA) system. The C-terminus may have RNase activity and probably inhibits growth. Its toxic effects are probably neutralized by its cognate antitoxin YwqK, but not by antitoxins specific to other toxins with the LXG domain (By similarity).
   
  
 0.937
yxiB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.934
rttG
Phage ribonuclease toxin; Toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 379-531) has RNase activity, and inhibits growth upon expression in E.coli. In vitro RNase activity and in vivo growth inhibition are neutralized by cognate antitoxin YqcF, but not by antitoxins specific to other toxins with the LXG domain.
 
 
  
 0.929
yeeF
Putative DNA binding protein; Probable toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 500-669) may have RNase activity and probably inhibits growth. Its toxic effects are probably neutralized by its cognate antitoxin YezG, but not by antitoxins specific to other toxins with the LXG domain (Probable).
 
  
 0.923
yezG
Conserved hypothetical protein; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Probably neutralizes the ability to inhibit growth of cognate toxin YeeF. Probably does not have antitoxin activity on other toxins with the LXG toxin domain (Probable).
  
 
 0.922
rttM
Antitoxin inhibiting Rnase RttL; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the RNase activity of cognate toxin YobL, as well as its ability to inhibit growth upon expression in E.coli. Does not have antitoxin activity on other toxins with the LXG toxin domain.
  
  
 0.921
rttL
Phage toxin ribonuclease; Toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 449-600) has RNase activity, and inhibits growth upon expression in E.coli. In vitro RNase activity and in vivo growth inhibition are neutralized by cognate antitoxin YobK, but not by antitoxins specific to other toxins with the LXG domain.
 
 
  
 0.919
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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