node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
csbC | hutM | BSU39810 | BSU39390 | Putative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Histidine permease; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. | 0.683 |
csbC | iolS | BSU39810 | BSU39780 | Putative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | 0.755 |
hutM | csbC | BSU39390 | BSU39810 | Histidine permease; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. | Putative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.683 |
hutM | iolS | BSU39390 | BSU39780 | Histidine permease; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | 0.759 |
iolI | iolR | BSU39680 | BSU39770 | Inosose isomerase; Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1- keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone). Belongs to the IolI family. | Transcriptional regulator (DeoR family); Iol operon repressor. | 0.829 |
iolI | iolS | BSU39680 | BSU39780 | Inosose isomerase; Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1- keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone). Belongs to the IolI family. | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | 0.519 |
iolI | mmsA | BSU39680 | BSU39760 | Inosose isomerase; Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1- keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone). Belongs to the IolI family. | Methylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. | 0.988 |
iolR | iolI | BSU39770 | BSU39680 | Transcriptional regulator (DeoR family); Iol operon repressor. | Inosose isomerase; Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1- keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone). Belongs to the IolI family. | 0.829 |
iolR | iolS | BSU39770 | BSU39780 | Transcriptional regulator (DeoR family); Iol operon repressor. | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | 0.739 |
iolR | mmsA | BSU39770 | BSU39760 | Transcriptional regulator (DeoR family); Iol operon repressor. | Methylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. | 0.973 |
iolS | csbC | BSU39780 | BSU39810 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Putative sugar transporter; Could serve either a nutritional or an osmotic protection function; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.755 |
iolS | hutM | BSU39780 | BSU39390 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Histidine permease; Evidence 2b: Function of strongly homologous gene; Product type t: transporter. | 0.759 |
iolS | iolI | BSU39780 | BSU39680 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Inosose isomerase; Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1- keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone). Belongs to the IolI family. | 0.519 |
iolS | iolR | BSU39780 | BSU39770 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Transcriptional regulator (DeoR family); Iol operon repressor. | 0.739 |
iolS | mmsA | BSU39780 | BSU39760 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Methylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. | 0.561 |
iolS | pksJ | BSU39780 | BSU17180 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.517 |
iolS | ydeA | BSU39780 | BSU05110 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Putative enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase C56 family. | 0.720 |
iolS | ytbE | BSU39780 | BSU29050 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Putative aldo/keto reductase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the aldo/keto reductase family. | 0.590 |
iolS | yvgN | BSU39780 | BSU33400 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Glyoxal/methylglyoxal reductase; Reduces glyoxal and methylglyoxal (2-oxopropanal). Is not involved in the vitamin B6 biosynthesis; Belongs to the aldo/keto reductase family. | 0.555 |
iolS | ywbC | BSU39780 | BSU38370 | Aldo-keto reductase; In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo- inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate. The physiological function of this enzyme is not clear. Does not seem to be necessary for inositol catabolism ; Belongs to the [...] | Putative lyase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the glyoxalase I family. | 0.699 |