STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yxaLMembrane associated protein kinase with beta-propeller domain; Increases the processivity of the PcrA helicase, but does not bind to DNA. (410 aa)    
Predicted Functional Partners:
yncE
Putative prophage protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin.
      
 0.969
ywhK
Factor interacting with DNA helicase PcrA; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor.
     
 0.924
pcrA
ATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair.
   
 
 0.871
yerB
Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein.
   
  
 0.850
hepA
ATPase involved in RNA remodelling DNA recombination and repair; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type f: factor; Belongs to the SNF2/RAD54 helicase family.
      
 0.681
yxdK
Two-component sensor histidine kinase [YxdJ]; Probable member of the two-component regulatory system YxdK/YxdJ. May activate YxdJ in response to the antibacterial protein LL-37.
      
 0.680
yxaJ
Putative integral membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
  
    0.649
yxbA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 17083466.
   
  
 0.647
yxdJ
Two-component response regulator [YxdK]; Probable member of the two-component regulatory system YxdK/YxdJ. Positively regulates the expression of the yxdLMyxeA operon by direct interaction with its promoter region. Could also indirectly regulate the expression of the dlt operon.
      
 0.638
yxeK
Putative monooxygenase; Probably catalyzes the oxygenation of the 2-position of the succinyl moiety of N-acetyl-S-(2-succino)cysteine, causing a spontaneous elimination reaction of the resulting hemithioketal that generates oxaloacetate and N-acetylcysteine (NAC). Is involved in a S- (2-succino)cysteine (2SC) degradation pathway that allows B.subtilis to grow on 2SC as a sole sulfur source, via its metabolization to cysteine; Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family.
      
 0.594
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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