Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yydFPeptide controlling LiaRS; Suggested to be the precursor for an exported, modified peptide that has antimicrobial and/or signaling properties. Synthesis requires YydG and YydH; the peptide is proposed to be exported by the YydIJ transporter. In the absence of the transporter, the modified peptide activates the LiaRS two-component regulatory system, possibly by eliciting cell envelope stress. This activation can occur in trans in cocultured cells lacking either the transporter or the whole operon. (49 aa)    
Predicted Functional Partners:
yydG
Putative AdoMet radical enzyme; Required for production of the modified peptide YydF (Probable). May activate a metalloenzyme (Potential).
  
  
 0.923
yorD
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
   
  
 0.907
yydH
Putative membrane metalloprotease; Required for production of the modified peptide YydF (Probable). May process the precursor form of YydF to release the active peptide (Potential); Belongs to the peptidase M50B family.
  
  
 0.900
yydI
ABC transporter (ATP-binding protein); Suggested to be part of an ABC transporter complex YydIJ involved in export of the modified peptide YydF (Probable). Responsible for energy coupling to the transport system (By similarity).
  
  
 0.810
yomK
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
   
  
 0.635
yydJ
Putative permease for export of a regulatory peptide; Suggested to be part of an ABC transporter complex YydIJ involved in export of the modified peptide YydF.
  
  
 0.603
yczC
Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
   
  
 0.563
spbC
Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...]
   
  
 0.544
rapA
Response regulator aspartate phosphatase; Prevents sporulation by dephosphorylating Spo0F. Belongs to the RAP family.
   
    0.531
ybdO
Putative phage protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin.
   
  
 0.524
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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