| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| sacT | sda | BSU38070 | BSU25690 | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | 0.483 |
| sacT | tsaC | BSU38070 | BSU36950 | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | 0.487 |
| sacT | vpr | BSU38070 | BSU38090 | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | Extracellular serine protease; Not required for growth or sporulation. | 0.449 |
| sacT | ywcI | BSU38070 | BSU38080 | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.967 |
| sacT | yydD | BSU38070 | BSU40200 | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.426 |
| sacT | yyzF | BSU38070 | BSU40239 | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.768 |
| sda | sacT | BSU25690 | BSU38070 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | 0.483 |
| sda | tsaC | BSU25690 | BSU36950 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | 0.689 |
| sda | vpr | BSU25690 | BSU38090 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Extracellular serine protease; Not required for growth or sporulation. | 0.633 |
| sda | ydiF | BSU25690 | BSU05950 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Putative ABC transporter (ATP-binding protein); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the ABC transporter superfamily. ABCF family. YdiF subfamily. | 0.633 |
| sda | yqeG | BSU25690 | BSU25680 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.852 |
| sda | ywcI | BSU25690 | BSU38080 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.797 |
| sda | yycS | BSU25690 | BSU40240 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Putative integrase/transposase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin. | 0.752 |
| sda | yydA | BSU25690 | BSU40230 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.688 |
| sda | yyzF | BSU25690 | BSU40239 | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.683 |
| tsaC | sacT | BSU36950 | BSU38070 | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | Transcriptional antiterminator; Mediates positive regulation of the sacPA operon by functioning as an antiterminator factor of transcription; Belongs to the transcriptional antiterminator BglG family. | 0.487 |
| tsaC | sda | BSU36950 | BSU25690 | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | Check point factor coupling initiation of sporulation and replication initiation; Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect [...] | 0.689 |
| tsaC | vpr | BSU36950 | BSU38090 | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | Extracellular serine protease; Not required for growth or sporulation. | 0.689 |
| tsaC | ydiF | BSU36950 | BSU05950 | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | Putative ABC transporter (ATP-binding protein); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the ABC transporter superfamily. ABCF family. YdiF subfamily. | 0.703 |
| tsaC | yqeG | BSU36950 | BSU25680 | tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi; Belongs to the SUA5 family. | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.758 |