node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
htrC | pksJ | BSU40360 | BSU17180 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.593 |
htrC | rseP | BSU40360 | BSU16560 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | 0.616 |
htrC | sleB | BSU40360 | BSU22930 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Spore cortex-lytic enzyme; Could be a lytic transglycosylase. Required for spore cortex hydrolysis during germination. Interacts strongly but noncovalently with spore components. | 0.681 |
htrC | walH | BSU40360 | BSU40390 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | 0.917 |
htrC | walJ | BSU40360 | BSU40370 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | 0.954 |
htrC | walK | BSU40360 | BSU40400 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.874 |
htrC | walR | BSU40360 | BSU40410 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Two-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. | 0.891 |
htrC | wprA | BSU40360 | BSU10770 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Cell wall-associated protease; CWBP52 is a serine-type protease that could be involved in proteoglycan peptide bridges; Belongs to the peptidase S8 family. | 0.579 |
htrC | ypeB | BSU40360 | BSU22920 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Spore membrane component; Required for spore cortex hydrolysis during germination. Appears to be required for either expression, localization, activation or function of SleB. | 0.755 |
htrC | yycI | BSU40360 | BSU40380 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Regulator of YycFG; Together with YycH, regulates the activity of the two- component system WalR/WalK. | 0.909 |
pksJ | htrC | BSU17180 | BSU40360 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | 0.593 |
pksJ | wprA | BSU17180 | BSU10770 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Cell wall-associated protease; CWBP52 is a serine-type protease that could be involved in proteoglycan peptide bridges; Belongs to the peptidase S8 family. | 0.487 |
rseP | htrC | BSU16560 | BSU40360 | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | 0.616 |
sleB | htrC | BSU22930 | BSU40360 | Spore cortex-lytic enzyme; Could be a lytic transglycosylase. Required for spore cortex hydrolysis during germination. Interacts strongly but noncovalently with spore components. | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | 0.681 |
sleB | ypeB | BSU22930 | BSU22920 | Spore cortex-lytic enzyme; Could be a lytic transglycosylase. Required for spore cortex hydrolysis during germination. Interacts strongly but noncovalently with spore components. | Spore membrane component; Required for spore cortex hydrolysis during germination. Appears to be required for either expression, localization, activation or function of SleB. | 0.999 |
walH | htrC | BSU40390 | BSU40360 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | 0.917 |
walH | walJ | BSU40390 | BSU40370 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | 0.992 |
walH | walK | BSU40390 | BSU40400 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.999 |
walH | walR | BSU40390 | BSU40410 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Two-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. | 0.992 |
walH | yycI | BSU40390 | BSU40380 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Regulator of YycFG; Together with YycH, regulates the activity of the two- component system WalR/WalK. | 0.999 |