STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
yyaRPutative acetyl-transferase; Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin; Belongs to the acetyltransferase family. GNAT subfamily. (173 aa)    
Predicted Functional Partners:
yyaO
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
   
  
 0.883
aadK
Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE.
 
  
 0.754
ycbJ
Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the aminoglycoside phosphotransferase family.
      
 0.746
fosB
Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.
  
   
 0.716
yitI
Putative N-acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the acetyltransferase family.
      
 0.633
tetB
Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family.
   
  
 0.628
ywoF
Putative pectate lyase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
    0.582
yvcP
Two-component response regulator [YvcQ]; Member of the two-component regulatory system YvcQ/YvcP.
   
  
 0.571
tmrB
ATP-binding tunicamycin resistance protein; Involved in the resistance to tunicamycin. Binds ATP.
  
   
 0.524
gntR
Transcriptional regulator (GntR family); Transcriptional repressor of the gluconate operon (gntRKPZ), which encodes the proteins for gluconate utilization. Represses mRNA synthesis by binding to the gnt operator; the binding is suppressed by gluconate or glucono-delta-lactone.
  
    0.497
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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