Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aadK | penP | BSU26790 | BSU18800 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | 0.567 |
| aadK | tetB | BSU26790 | BSU40770 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.491 |
| aadK | vmlR | BSU26790 | BSU05610 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | ATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] | 0.915 |
| aadK | yyaR | BSU26790 | BSU40740 | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | Putative acetyl-transferase; Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin; Belongs to the acetyltransferase family. GNAT subfamily. | 0.831 |
| dfrA | gyrA | BSU21810 | BSU00070 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | DNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.787 |
| dfrA | rpsL | BSU21810 | BSU01100 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Ribosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. | 0.691 |
| dfrA | tetB | BSU21810 | BSU40770 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.703 |
| gyrA | dfrA | BSU00070 | BSU21810 | DNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.787 |
| gyrA | rpsL | BSU00070 | BSU01100 | DNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Ribosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. | 0.949 |
| gyrA | tetB | BSU00070 | BSU40770 | DNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.682 |
| penP | aadK | BSU18800 | BSU26790 | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | 0.567 |
| penP | tetB | BSU18800 | BSU40770 | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.568 |
| rpsL | dfrA | BSU01100 | BSU21810 | Ribosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.691 |
| rpsL | gyrA | BSU01100 | BSU00070 | Ribosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. | DNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.949 |
| rpsL | tetB | BSU01100 | BSU40770 | Ribosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.845 |
| rpsL | vmlR | BSU01100 | BSU05610 | Ribosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. | ATP-binding cassette efflux transporter; Recognizes and binds in the vacant E-site of ribosomes stalled by some peptidyltransferase center (PTC)-targeting antibiotics. Makes contact with the PTC and both ribosomal subunits. Induces conformational changes in the P-site, which allows it to dislodge the antibiotic from its PTC binding site. Binds to ribosomes either directly following translation initation or subsequent to E tRNA release during elongation. Involved in resistance to a narrow spectrum of antibiotics (the streptogramin A antibiotic virginiamycin M, the lincosamide antibiotic [...] | 0.939 |
| tetB | aadK | BSU40770 | BSU26790 | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | Aminoglycoside 6-adenylyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; To E.faecalis AadE. | 0.491 |
| tetB | dfrA | BSU40770 | BSU21810 | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.703 |
| tetB | gyrA | BSU40770 | BSU00070 | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | DNA gyrase (subunit A); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.682 |
| tetB | penP | BSU40770 | BSU18800 | Multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter; Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal- tetracycline/H(+) antiporter; Belongs to the major facilitator superfamily. TCR/Tet family. | Beta-lactamase precursor; This protein is a beta-lactamase with a substrate specificity for penicillins. | 0.568 |
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