STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypDHydrogenase expression/formation protein HypD. (380 aa)    
Predicted Functional Partners:
hypE
Hydrogenase expression/formation protein.
 
 0.998
hypB
Hydrogenase expression/formation protein B.
 
  
 0.903
hypF
Transcriptional regulatory protein HypF.
 
  
 0.880
mbhL3
Hydrogenase large subunit.
 
 
 0.825
hoxX
Hydrogenase regulation HoxX; Belongs to the enoyl-CoA hydratase/isomerase family.
  
    0.817
hisS2
histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
       0.757
hypA
Hydrogenase accessory protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.737
hupD
HupD hydrogenase related function.
 
   
 0.496
mbhS3
Hydrogenase small subunit.
 
  
 0.473
topG1
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
       0.428
Your Current Organism:
Aquifex aeolicus
NCBI taxonomy Id: 224324
Other names: A. aeolicus VF5, Aquifex aeolicus VF5, Aquifex aeolicus str. VF5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.