node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | aq_236 | aq_1303 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.852 |
guaA | hisF | aq_236 | aq_181 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.513 |
guaA | hisH | aq_236 | aq_732 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.516 |
hisA | guaA | aq_1303 | aq_236 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.852 |
hisA | hisB | aq_1303 | aq_039 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerolphosphate dehydratase. | 0.986 |
hisA | hisC | aq_1303 | aq_2084 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.980 |
hisA | hisD | aq_1303 | aq_782 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisF | aq_1303 | aq_181 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.996 |
hisA | hisG | aq_1303 | aq_1613 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.982 |
hisA | hisH | aq_1303 | aq_732 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisIE | aq_1303 | aq_1968 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-ATP pyrophosphohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | hisS2 | aq_1303 | aq_1155 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.945 |
hisA | trpC | aq_1303 | aq_1787 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.836 |
hisB | hisA | aq_039 | aq_1303 | Imidazoleglycerolphosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.986 |
hisB | hisC | aq_039 | aq_2084 | Imidazoleglycerolphosphate dehydratase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | aq_039 | aq_782 | Imidazoleglycerolphosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisB | hisF | aq_039 | aq_181 | Imidazoleglycerolphosphate dehydratase. | HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.998 |
hisB | hisG | aq_039 | aq_1613 | Imidazoleglycerolphosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.984 |
hisB | hisH | aq_039 | aq_732 | Imidazoleglycerolphosphate dehydratase. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.998 |
hisB | hisIE | aq_039 | aq_1968 | Imidazoleglycerolphosphate dehydratase. | phosphoribosyl-ATP pyrophosphohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |