trpC protein (Aquifex aeolicus) - STRING interaction network

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Score

trpC

Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (257 aa)

Predicted Functional Partners:

trpA

0.999

trpD1

0.999

trpF

0.999

trpG

0.999

trpE

0.999

trpB1

0.999

pabB

0.995

trpD2

0.973

trpB2

0.942

hisA

0.836

Your Current Organism:

Aquifex aeolicus

NCBI taxonomy Id: 224324
Other names: A. aeolicus VF5, Aquifex aeolicus VF5, Aquifex aeolicus str. VF5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hisA	trpC	aq_1303	aq_1787	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.836
pabB	trpA	aq_1144	aq_1548	P-aminobenzoate synthetase.	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.868
pabB	trpB1	aq_1144	aq_706	P-aminobenzoate synthetase.	Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.886
pabB	trpC	aq_1144	aq_1787	P-aminobenzoate synthetase.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.995
pabB	trpD1	aq_1144	aq_196	P-aminobenzoate synthetase.	Phosphoribosylanthranilate transferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.996
pabB	trpD2	aq_1144	aq_209	P-aminobenzoate synthetase.	Phosphoribosylanthranilate transferase; Belongs to the anthranilate phosphoribosyltransferase family.	0.984
pabB	trpE	aq_1144	aq_582	P-aminobenzoate synthetase.	Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]	0.836
pabB	trpF	aq_1144	aq_2076	P-aminobenzoate synthetase.	Phosphoribosyl anthranilate isomerase; Belongs to the TrpF family.	0.875
pabB	trpG	aq_1144	aq_549	P-aminobenzoate synthetase.	Anthranilate synthase component II.	0.999
trpA	pabB	aq_1548	aq_1144	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	P-aminobenzoate synthetase.	0.868
trpA	trpB1	aq_1548	aq_706	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.999
trpA	trpB2	aq_1548	aq_1410	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.999
trpA	trpC	aq_1548	aq_1787	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.999
trpA	trpD1	aq_1548	aq_196	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Phosphoribosylanthranilate transferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.990
trpA	trpD2	aq_1548	aq_209	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Phosphoribosylanthranilate transferase; Belongs to the anthranilate phosphoribosyltransferase family.	0.969
trpA	trpE	aq_1548	aq_582	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]	0.909
trpA	trpF	aq_1548	aq_2076	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Phosphoribosyl anthranilate isomerase; Belongs to the TrpF family.	0.986
trpA	trpG	aq_1548	aq_549	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	Anthranilate synthase component II.	0.961
trpB1	pabB	aq_706	aq_1144	Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	P-aminobenzoate synthetase.	0.886
trpB1	trpA	aq_706	aq_1548	Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.999