STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobBHypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. (239 aa)    
Predicted Functional Partners:
nadE
NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.949
nadD
Hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
 0.928
pncA
Pyrazinamidase/nicotinamidase.
  
 0.921
nadK
Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
   
 
 0.920
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
      
 0.869
dnaK
Hsp70 chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
    
 0.794
aq_2171
Hypothetical protein.
       0.773
aq_2172
Putative protein.
       0.773
aq_2173
Putative protein.
       0.773
ihfB
Integration host factor beta subunit; Belongs to the bacterial histone-like protein family.
       0.773
Your Current Organism:
Aquifex aeolicus
NCBI taxonomy Id: 224324
Other names: A. aeolicus VF5, Aquifex aeolicus VF5, Aquifex aeolicus str. VF5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.