Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobS1Cobalamin (5'-phosphate) synthase (cobS-1); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. (265 aa)    
Predicted Functional Partners:
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
 
  
 0.994
AF_2321
Conserved hypothetical protein; Similar to GB:L77117 PID:1591756 percent identity: 40.12; identified by sequence similarity; putative.
 
  
  0.942
AF_1290
Conserved hypothetical protein; Similar to SP:P45515 PID:493088 percent identity: 31.54; identified by sequence similarity; putative.
    
 0.927
cobS2
Cobalamin (5'-phosphate) synthase (cobS-2); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family.
  
  
 
0.903
cobQ
Cobyric acid synthase (cbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.795
pcm1
L-isoaspartyl protein carboxyl methyltransferase (pcm-1); Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).
       0.788
AF_0727
Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family.
  
  
 0.743
cbiA
Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.701
cobD
Cobalamin biosynthesis protein (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
   
 0.687
AF_0276
Conserved hypothetical protein; Similar to GB:L77117 PID:1500495 percent identity: 40.12; identified by sequence similarity; putative; Belongs to the UPF0284 family.
 
  
 0.655
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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