Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tmkThymidylate kinase (tmk); Similar to SP:P37345 PID:1244710 GB:U00096 PID:1787340 percent identity: 34.87; identified by sequence similarity; putative. (196 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.988
dut
Deoxycytidine triphosphate deaminase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.955
AF_1664
Ribonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.942
AF_2047
Thymidylate synthase, putative; Similar to GB:M19653 SP:P00469 PID:149601 percent identity: 33.14; identified by sequence similarity; putative.
  
 
 0.942
AF_1764
dCMP deaminase, putative; Similar to SP:P06773 PID:171384 PID:500658 percent identity: 39.04; identified by sequence similarity; putative.
    
 0.927
surE
surE stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.922
AF_1308
Thymidylate kinase, putative; Similar to GB:L77117 SP:Q57741 PID:1591015 percent identity: 26.32; identified by sequence similarity; putative.
 
  
 
0.906
AF_0060
Predicted coding region AF_0060; Hypothetical protein; identified by GeneMark; putative.
       0.773
AF_1645
Pantothenate metabolism flavoprotein (dfp); Similar to GB:L77117 PID:1591587 percent identity: 42.42; identified by sequence similarity; putative.
  
  
 0.700
AF_0055
Conserved hypothetical protein; Similar to GB:L77117 PID:1592056 percent identity: 48.00; identified by sequence similarity; putative; Belongs to the UPF0107 family.
       0.655
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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