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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AF_0111Conserved hypothetical protein; Similar to GB:L77117 SP:Q58629 PID:1591864 percent identity: 40.07; identified by sequence similarity; putative. (299 aa)    
Predicted Functional Partners:
AF_0211
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58799 PID:1592053 percent identity: 30.77; identified by sequence similarity; putative.
   
    0.623
tfe
Transcription initiation factor IIE, subunit alpha, putative; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and dest [...]
  
     0.603
AF_2363
Conserved hypothetical protein; Similar to GB:L77117 PID:1500295 percent identity: 54.77; identified by sequence similarity; putative.
  
     0.572
AF_0848
Conserved hypothetical protein; Similar to GB:L77117 PID:1591856 percent identity: 34.78; identified by sequence similarity; putative.
  
    0.516
cobB2
Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
       0.509
AF_2427
Predicted coding region AF_2427; Hypothetical protein; identified by GeneMark; putative.
  
     0.476
AF_0998
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57978 PID:1591264 percent identity: 27.52; identified by sequence similarity; putative.
  
     0.472
cofC
Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
  
     0.466
AF_1396
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58217 PID:1591499 percent identity: 44.68; identified by sequence similarity; putative.
  
    0.464
AF_0934
Conserved hypothetical protein; Similar to GB:L77117 PID:1500498 percent identity: 31.88; identified by sequence similarity; putative.
  
     0.457
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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