Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AF_0116Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (226 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
 0.997
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
     
 0.983
hemB
Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
 
 
 0.976
AF_1243
uroporphyrin-III C-methyltransferase (cysG-2); Similar to GB:L77117 PID:1591629 percent identity: 52.52; identified by sequence similarity; putative.
 
 
 0.950
AF_0422
uroporphyrin-III C-methyltransferase (cysG-1); Similar to GB:L77117 PID:1591629 percent identity: 41.74; identified by sequence similarity; putative.
 
 
 0.949
hemA
glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.878
hemL
Glutamate-1-semialdehyde aminotransferase (hemL); Similar to GB:L77117 SP:Q58020 PID:1591312 percent identity: 54.31; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
  
 0.862
AF_0218
TRK potassium uptake system protein (trkA-1); Similar to GB:X74307 SP:P39449 PID:414170 percent identity: 30.17; identified by sequence similarity; putative.
  
    0.809
AF_0115
Conserved hypothetical protein; Similar to GB:X52543 PID:46506 SP:P55177 percent identity: 31.85; identified by sequence similarity; putative.
     
 0.802
AF_1592
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57605 PID:1590903 percent identity: 30.69; identified by sequence similarity; putative.
 
  
 0.801
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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