Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0117Pyruvate formate-lyase activating enzyme (act-1); Similar to GB:L77117 PID:1591858 percent identity: 25.47; identified by sequence similarity; putative. (320 aa)    
Predicted Functional Partners:
AF_2278
Pyruvate formate-lyase activating enzyme (act-4); Similar to GB:L77117 SP:Q58218 PID:1499631 percent identity: 42.46; identified by sequence similarity; putative.
  
   
 0.800
AF_0118
Predicted coding region AF_0118; Hypothetical protein; identified by GeneMark; putative.
       0.773
AF_1449
Pyruvate formate-lyase 2 (pflD); Similar to SP:P32674 GB:U00006 PID:396298 GB:U00096 PID:1790388 percent identity: 37.81; identified by sequence similarity; putative.
  
  
 0.759
AF_1969
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58220 PID:1592310 percent identity: 55.84; identified by sequence similarity; putative.
 
     0.648
AF_2310
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57846 PID:1591108 percent identity: 47.01; identified by sequence similarity; putative; Belongs to the MEMO1 family.
 
     0.554
AF_1961
Pyruvate formate-lyase activating enzyme (pflX); Similar to PID:1016358 percent identity: 50.15; identified by sequence similarity; putative.
 
   
 0.534
AF_0119
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58031 PID:1591324 percent identity: 34.12; identified by sequence similarity; putative.
       0.521
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
  
 0.520
cdhA1
acetyl-CoA decarbonylase/synthase, subunit alpha (cdhA-1); Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
  
   
 0.502
AF_1938
Conserved hypothetical protein; Catalyzes the reversible conversion of a variety of acids to the corresponding acyl-CoA esters. Shows the highest activity with the aryl acids, indoleacetate and phenylacetate, as compared to acetate. In the reverse direction, phenylacetyl-CoA is the best substrate. Seems to be involved primarily in the degradation of aryl-CoA esters to the corresponding acids. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters. In the C-terminal section; belongs to the acetate CoA ligase alpha subunit family.
     
 0.499
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.