Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0130Acetylpolyamine aminohydrolase (aphA); Probable deacetylase; Belongs to the histone deacetylase family. (359 aa)    
Predicted Functional Partners:
AF_2350
ATP-dependent RNA helicase HepA, putative; Similar to SP:P54509 PID:1303889 GB:AL009126 percent identity: 31.49; identified by sequence similarity; putative.
   
 0.823
AF_0477
AAA superfamily ATPase; Similar to GB:D78275 SP:Q92524 PID:1526426 PID:2213932 percent identity: 34.97; identified by sequence similarity; putative; Belongs to the AAA ATPase family.
   
 0.793
AF_1297
Cell division control protein 48, AAA family (cdc48-1); Similar to GB:L77117 SP:Q58556 PID:1591785 percent identity: 69.10; identified by sequence similarity; putative; Belongs to the AAA ATPase family. CDC48 subfamily.
   
 0.793
AF_2098
Cell division control protein 48, AAA family (cdc48-2); Similar to GB:X79560 SP:P46464 PID:517390 percent identity: 61.98; identified by sequence similarity; putative.
   
 0.793
nfi
Conserved hypothetical protein; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Recognizes only deoxyinosine.
       0.773
rpl14
LSU ribosomal protein L14P (rpl14P); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
 
 
 
 0.768
smc
Chromosome segregation protein (smc1); Required for chromosome condensation and partitioning. Belongs to the SMC family.
 
 
 0.747
AF_1970
TPR domain-containing protein; Similar to GB:L04733 SP:Q07866 PID:307085 percent identity: 29.03; identified by sequence similarity; putative.
   
 0.746
AF_2369
Predicted coding region AF_2369; Hypothetical protein; identified by GeneMark; putative.
   
 0.746
cobB2
Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
   
 0.734
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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