Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0164Ferredoxin-nitrite reductase (nirA); Similar to PID:1001216 PID:1001208 percent identity: 29.72; identified by sequence similarity; putative. (436 aa)    
Predicted Functional Partners:
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
  
  
 0.986
glnA
Glutamine synthetase (glnA); Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Beta-glutamate is a much poorer substrate than alpha-glutamate; Belongs to the glutamine synthetase family.
    
 0.946
AF_0422
uroporphyrin-III C-methyltransferase (cysG-1); Similar to GB:L77117 PID:1591629 percent identity: 41.74; identified by sequence similarity; putative.
 
  
 0.943
AF_1243
uroporphyrin-III C-methyltransferase (cysG-2); Similar to GB:L77117 PID:1591629 percent identity: 52.52; identified by sequence similarity; putative.
 
  
 0.943
sat
Sulfate adenylyltransferase (sat); Similar to PID:1653421 percent identity: 28.39; identified by sequence similarity; putative; Belongs to the sulfate adenylyltransferase family.
 
  
 0.941
cysC
Adenylylsulfate 3-phosphotransferase (cysC); Catalyzes the synthesis of activated sulfate.
  
  
 0.929
trpCD
Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity).
     
 0.900
wtpB
Sulfate ABC transporter, permease protein (cysT); Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane (Probable); Belongs to the binding-protein-dependent transport system permease family.
  
  
 0.834
AF_0165
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58397 PID:1591652 percent identity: 34.38; identified by sequence similarity; putative.
  
    0.822
AF_0726
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Similar to GB:L77117 PID:1500473 percent identity: 49.16; identified by sequence similarity; putative.
 
   
 0.774
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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