Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0165Conserved hypothetical protein; Similar to GB:L77117 SP:Q58397 PID:1591652 percent identity: 34.38; identified by sequence similarity; putative. (77 aa)    
Predicted Functional Partners:
AF_0164
Ferredoxin-nitrite reductase (nirA); Similar to PID:1001216 PID:1001208 percent identity: 29.72; identified by sequence similarity; putative.
  
    0.822
AF_0183
Conserved hypothetical protein; Similar to SP:P54432 PID:1303704 GB:AL009126 percent identity: 32.11; identified by sequence similarity; putative.
  
  
 0.806
iscS1
nifS protein, class-V aminotransferase (nifS-1); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
   
 
 0.710
iscS2
nifS protein, class-V aminotransferase (nifS-2); Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 1 ligand while IscU provides the other 3 ligands. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
   
 
 0.710
AF_1670
Adenylylsulfate reductase, subunit A (aprA); Similar to GB:X63435 PID:38809 percent identity: 95.98; identified by sequence similarity; putative.
     
 0.690
AF_0163
Predicted coding region AF_0163; Hypothetical protein; identified by GeneMark; putative.
       0.590
AF_0555
Predicted coding region AF_0555; Hypothetical protein; identified by GeneMark; putative.
  
  
 0.418
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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