Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
htpXHeat shock protein (htpX); Similar to GB:L77117 PID:1592249 percent identity: 32.95; identified by sequence similarity; putative; Belongs to the peptidase M48B family. (335 aa)    
Predicted Functional Partners:
AF_1403
Conserved hypothetical protein; Similar to GB:L77117 PID:1592100 percent identity: 58.99; identified by sequence similarity; putative.
  
    0.879
rgy
Reverse gyrase (top-RG); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
   
 0.875
AF_1646
Conserved hypothetical protein; Similar to GB:L77117 PID:1591632 percent identity: 34.23; identified by sequence similarity; putative.
  
    0.863
alaS
alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Incorrectly charged aminoacyl-tRNA(Ala) is also edited in situ by the editing domain.
  
  
 0.826
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
 0.783
AF_2220
Predicted coding region AF_2220; Hypothetical protein; identified by GeneMark; putative.
  
 
 0.729
AF_0234
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58298 PID:1591566 percent identity: 36.94; identified by sequence similarity; putative.
  
  
 0.682
ilvD
Dihydroxy-acid dehydratase (ilvD); Similar to GB:L77117 PID:1591912 percent identity: 54.55; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.
  
 
 0.667
thsB
Thermosome, subunit beta (thsB); Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family.
  
 0.664
thsA
Thermosome, subunit alpha (thsA); Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family.
  
 0.664
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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