Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0241Conserved hypothetical protein; Similar to GB:L77117 PID:1500478 percent identity: 43.14; identified by sequence similarity; putative. (139 aa)    
Predicted Functional Partners:
AF_1281
Intracellular protease (pfpI); Similar to PID:1373331 percent identity: 56.02; identified by sequence similarity; putative; Belongs to the peptidase C56 family.
      0.657
AF_0431
Iron (III) ABC transporter, permease protein (hemU-1); Similar to GB:X77867 PID:541768 PID:1619624 percent identity: 36.22; identified by sequence similarity; putative.
       0.624
AF_0432
Iron (III) ABC transporter, ATP-binding protein (hemV-2); Similar to GB:L77117 SP:Q57550 PID:1590868 percent identity: 58.71; identified by sequence similarity; putative.
       0.624
AF_0242
Glucose-1-phosphate thymidylyltransferase (graD-1); Similar to PID:763512 percent identity: 27.69; identified by sequence similarity; putative.
  
    0.565
AF_0243
Conserved hypothetical protein; Similar to GB:L77117 PID:1590999 percent identity: 45.88; identified by sequence similarity; putative.
       0.560
kae1
O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
      
 0.510
fusA
Translation elongation factor EF-2 (fus); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor G [...]
  
  
 0.482
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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