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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
AF_0403Conserved hypothetical protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. To a much lesser extent, is also able to use heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) as the prenyl donor. Belongs to the GGGP/HepGP synthase family. Group I subfamily. (231 aa)    
Predicted Functional Partners:
AF_0404
4-hydroxybenzoate octaprenyltransferase, putative; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
  
 0.998
egsA
Sn-glycerol-1-phosphate dehydrogenase (gldA); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family.
  
  
 0.986
tpiA
Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
     
 0.920
AF_0866
Glycerol kinase (glpK); Similar to GB:M34393 SP:P18157 PID:142992 PID:2226137 GB:AL009126 percent identity: 33.83; identified by sequence similarity; putative; Belongs to the FGGY kinase family.
      
 0.853
gpsA
Glycerol-3-phosphate dehydrogenase (NAD(P)+) (gpsA); Similar to SP:P46919 PID:974332 PID:1146220 GB:AL009126 percent identity: 36.31; identified by sequence similarity; putative.
      
 0.838
AF_1551
Octaprenyl-diphosphate synthase (ispB); Similar to GB:L42023 SP:P44916 PID:1005963 PID:1220984 PID:1205128 percent identity: 33.20; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family.
      
 0.715
carS
Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. Can use CTP or dCTP, but not ATP, GTP or TTP; Belongs to the CDP-archaeol synthase family.
  
   
 0.671
AF_0402
Predicted coding region AF_0402; Hypothetical protein; identified by GeneMark; putative.
       0.642
AF_0401
Carbohydrate kinase, pfkB family; Similar to SP:P40713 PID:608707 percent identity: 34.10; identified by sequence similarity; putative.
       0.598
uppS
Conserved hypothetical protein; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
      
 0.532
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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