STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AF_04044-hydroxybenzoate octaprenyltransferase, putative; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (293 aa)    
Predicted Functional Partners:
AF_0403
Conserved hypothetical protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. To a much lesser extent, is also able to use heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) as the prenyl donor. Belongs to the GGGP/HepGP synthase family. Group I subfamily.
 
  
 0.998
AF_0464
Bacteriochlorophyll synthase, 43 kDa subunit (chlP-1); Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. Is not active with NADPH as an electron donor. Is not able to reduce the prenyl group of respiratory quinones; Belong [...]
 
 
 0.964
carS
Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. Can use CTP or dCTP, but not ATP, GTP or TTP; Belongs to the CDP-archaeol synthase family.
 
  
 0.945
egsA
Sn-glycerol-1-phosphate dehydrogenase (gldA); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family.
  
   
 0.930
gpsA
Glycerol-3-phosphate dehydrogenase (NAD(P)+) (gpsA); Similar to SP:P46919 PID:974332 PID:1146220 GB:AL009126 percent identity: 36.31; identified by sequence similarity; putative.
     
 0.895
AF_0866
Glycerol kinase (glpK); Similar to GB:M34393 SP:P18157 PID:142992 PID:2226137 GB:AL009126 percent identity: 33.83; identified by sequence similarity; putative; Belongs to the FGGY kinase family.
     
 0.885
AF_1637
Bacteriochlorophyll synthase, 43 kDa subunit (chlP-3); Similar to SP:P26172 PID:46117 percent identity: 27.03; identified by sequence similarity; putative.
 
  
 0.669
AF_1445
Conserved hypothetical protein; Similar to GP:1524204 percent identity: 26.18; identified by sequence similarity; putative.
 
  
 0.656
AF_0402
Predicted coding region AF_0402; Hypothetical protein; identified by GeneMark; putative.
       0.642
AF_1023
Bacteriochlorophyll synthase, 43 kDa subunit (chlP-2); Similar to GB:L77117 SP:Q58915 PID:1592151 percent identity: 31.22; identified by sequence similarity; putative.
 
  
 0.633
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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