Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0422uroporphyrin-III C-methyltransferase (cysG-1); Similar to GB:L77117 PID:1591629 percent identity: 41.74; identified by sequence similarity; putative. (243 aa)    
Predicted Functional Partners:
AF_1592
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57605 PID:1590903 percent identity: 30.69; identified by sequence similarity; putative.
 
 
 0.985
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.971
cbiHC
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Bifunctional enzyme with a methyltransferase domain that catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV, and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; In the C-terminal section; belongs to the CobH family.
  
  
 0.955
AF_0116
Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.949
AF_0164
Ferredoxin-nitrite reductase (nirA); Similar to PID:1001216 PID:1001208 percent identity: 29.72; identified by sequence similarity; putative.
 
  
 0.943
AF_0727
Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Similar to PID:1652770 percent identity: 31.46; identified by sequence similarity; putative; Belongs to the precorrin methyltransferase family.
  
 
 0.926
AF_1243
uroporphyrin-III C-methyltransferase (cysG-2); Similar to GB:L77117 PID:1591629 percent identity: 52.52; identified by sequence similarity; putative.
  
  
 
0.905
AF_0421
Predicted coding region AF_0421; Hypothetical protein; identified by GeneMark; putative.
       0.697
cysC
Adenylylsulfate 3-phosphotransferase (cysC); Catalyzes the synthesis of activated sulfate.
  
  
 0.689
AF_0418
Conserved hypothetical protein; Similar to GB:L77117 PID:1591840 percent identity: 26.21; identified by sequence similarity; putative.
       0.678
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.