Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AF_0519Predicted coding region AF_0519; Hypothetical protein; identified by GeneMark; putative. (149 aa)    
Predicted Functional Partners:
kae1
O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
    
 
 0.888
AF_0665
O-sialoglycoprotein endopeptidase, putative; Could be involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
    
 
 0.884
AF_0518
Conserved hypothetical protein; Similar to GB:L77117 PID:1592003 percent identity: 34.55; identified by sequence similarity; putative.
       0.807
aroK
Conserved hypothetical protein; Similar to GB:L77117 PID:1500322 percent identity: 34.44; identified by sequence similarity; putative.
       0.773
AF_0517
Cell division control protein 21 (cdc21); Similar to GB:L77117 SP:Q57809 PID:1591071 percent identity: 32.75; identified by sequence similarity; putative; Belongs to the MCM family.
       0.634
AF_0569
DR-beta chain MHC class II; Similar to GP:1223616 percent identity: 37.74; identified by sequence similarity; putative.
       0.554
AF_0516
Predicted coding region AF_0516; Hypothetical protein; identified by GeneMark; putative.
       0.541
rps17e
SSU ribosomal protein S17E (rps17E); Similar to PIR:S63968 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS17 family.
       0.516
AF_0364
ATP-dependent protease La (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
       0.486
AF_1247
Conserved hypothetical protein; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
       0.443
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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