Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AF_0556Conserved hypothetical protein; Similar to SP:P54436 PID:1303708 GB:AL009126 percent identity: 33.33; identified by sequence similarity; putative; Belongs to the sulfur carrier protein TusA family. (73 aa)    
Predicted Functional Partners:
AF_0555
Predicted coding region AF_0555; Hypothetical protein; identified by GeneMark; putative.
 
  
 0.917
AF_0557
Flavoprotein reductase; Similar to GP:1480407 percent identity: 26.19; identified by sequence similarity; putative.
 
   
 0.839
AF_0558
Conserved hypothetical protein; Similar to GP:1934608 percent identity: 24.44; identified by sequence similarity; putative.
       0.777
iscS1
nifS protein, class-V aminotransferase (nifS-1); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
   
 
 0.710
iscS2
nifS protein, class-V aminotransferase (nifS-2); Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 1 ligand while IscU provides the other 3 ligands. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
   
 
 0.710
AF_0183
Conserved hypothetical protein; Similar to SP:P54432 PID:1303704 GB:AL009126 percent identity: 32.11; identified by sequence similarity; putative.
 
  
 0.608
AF_0559
Conserved hypothetical protein; Similar to PID:1652988 percent identity: 38.22; identified by sequence similarity; putative.
  
    0.597
AF_0552
Conserved hypothetical protein; Similar to PID:1653220 percent identity: 37.08; identified by sequence similarity; putative; Belongs to the sulfur carrier protein CysO family.
   
 
 0.557
AF_0553
Thiamine biosynthesis protein (thiF); Similar to SP:P30138 PID:396331 PID:414234 GB:U00096 PID:1790425 percent identity: 38.75; identified by sequence similarity; putative.
     
 0.535
AF_0551
Threonine synthase (thrC-1); Similar to GB:L77117 PID:1592106 percent identity: 40.50; identified by sequence similarity; putative.
       0.458
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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