Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0565nifU protein (nifU-2); Similar to GB:L42023 PID:1003638 PID:1222302 PID:1204625 PID:1573346 percent identity: 55.65; identified by sequence similarity; putative. (153 aa)    
Predicted Functional Partners:
iscS2
nifS protein, class-V aminotransferase (nifS-2); Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 1 ligand while IscU provides the other 3 ligands. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 0.999
iscS1
nifS protein, class-V aminotransferase (nifS-1); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
 0.964
AF_2364
ABC transporter, ATP-binding protein; Similar to PID:747641 GB:AE000666 percent identity: 52.65; identified by sequence similarity; putative.
  
  
 0.869
AF_2365
Conserved hypothetical protein; Similar to PID:726070 GB:AE000666 percent identity: 46.36; identified by sequence similarity; putative; Belongs to the UPF0051 (ycf24) family.
  
  
 0.866
AF_0632
nifU protein (nifU-3); Similar to PID:1653754 percent identity: 47.37; identified by sequence similarity; putative.
  
 
 0.831
iscU1
nifU protein (nifU-1); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). Belongs to the NifU family.
  
 
  
0.801
AF_0566
Conserved hypothetical protein; Similar to GP:1707787 percent identity: 33.90; identified by sequence similarity; putative.
       0.790
AF_0563
Conserved hypothetical protein; Similar to GP:1772578 percent identity: 30.77; identified by sequence similarity; putative.
       0.778
AF_0682
Succinate dehydrogenase, iron-sulfur subunit B (sdhB); Similar to GB:X70908 PID:396212 percent identity: 51.27; identified by sequence similarity; putative.
   
 0.759
AF_0270
Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.599
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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