STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AF_0580Exodeoxyribonuclease III (xthA); Similar to PID:1653682 percent identity: 41.31; identified by sequence similarity; putative. (257 aa)    
Predicted Functional Partners:
nth
Endonuclease III (nth); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.995
fen
DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...]
  
 0.989
pcn
Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 0.977
AF_1725
DNA ligase, putative; Similar to SP:P54875 GB:AE000666 PID:1279773 percent identity: 32.69; identified by sequence similarity; putative.
 
 
 0.976
AF_2117
3-methyladenine DNA glycosylase (alkA); Similar to GB:D14465 SP:P37878 PID:436209 GB:AL009126 percent identity: 30.05; identified by sequence similarity; putative.
  
 0.944
AF_0362
snRNP, putative; Similar to GP:1627855 percent identity: 32.00; identified by sequence similarity; putative.
   
 0.854
AF_0875
snRNP, putative; Similar to GB:X85372 PID:806564 percent identity: 35.71; identified by sequence similarity; putative; Belongs to the snRNP Sm proteins family.
   
 0.854
pol
DNA polymerase B1 (polB); Similar to PID:807830 percent identity: 45.13; identified by sequence similarity; putative.
  
 0.840
AF_0581
dolichol-P-glucose synthetase, putative; Similar to GB:L77117 SP:Q58619 PID:1591853 percent identity: 27.50; identified by sequence similarity; putative.
     
 0.813
AF_0817
Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative.
   
 
 0.802
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.