Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0646Agmatinase (speB); Similar to GB:M32363 SP:P16936 PID:147859 PID:551839 PID:882466 percent identity: 33.33; identified by sequence similarity; putative; Belongs to the arginase family. (275 aa)    
Predicted Functional Partners:
speE
Spermidine synthase (speE); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
 
 
 0.981
eif5a
Translation initiation factor eIF-5A (eif5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
  
  
 0.946
pdaD1
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57764 PID:1591036 percent identity: 38.26; identified by sequence similarity; putative; Belongs to the PdaD family.
    
 0.919
pdaD2
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57764 PID:1591036 percent identity: 32.67; identified by sequence similarity; putative; Belongs to the PdaD family.
    
 0.919
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
  
 
 0.820
leuS
leucyl-tRNA synthetase (leuS); Similar to GB:L77117 SP:Q58050 PID:1591345 percent identity: 49.68; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.773
mdh
L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate.
  
 
 0.764
AF_0364
ATP-dependent protease La (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
    
  0.763
AF_0921
Predicted coding region AF_0921; Hypothetical protein; identified by GeneMark; putative.
  
  
 0.733
icd
Isocitrate dehydrogenase, NADP (icd); Similar to GB:J02799 SP:P08200 PID:146432 GB:U00096 PID:1651560 percent identity: 57.18; identified by sequence similarity; putative; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.714
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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