| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AF_0465 | dnaG | AF_0465 | AF_1899 | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.401 |
| AF_0465 | gyrB | AF_0465 | AF_0530 | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.999 |
| AF_0465 | pcn | AF_0465 | AF_0335 | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.502 |
| AF_0465 | top6A | AF_0465 | AF_0940 | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | DNA topoisomerase VI, subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.669 |
| AF_0465 | top6B | AF_0465 | AF_0652 | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | DNA topoisomerase VI, subunit B (top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.827 |
| AF_0651 | top6A | AF_0651 | AF_0940 | Predicted coding region AF_0651; Hypothetical protein; identified by GeneMark; putative. | DNA topoisomerase VI, subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.681 |
| AF_0651 | top6B | AF_0651 | AF_0652 | Predicted coding region AF_0651; Hypothetical protein; identified by GeneMark; putative. | DNA topoisomerase VI, subunit B (top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.906 |
| dnaG | AF_0465 | AF_1899 | AF_0465 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | 0.401 |
| dnaG | gyrB | AF_1899 | AF_0530 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.710 |
| dnaG | pcn | AF_1899 | AF_0335 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.808 |
| dnaG | priL | AF_1899 | AF_0336 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.848 |
| dnaG | priS | AF_1899 | AF_0742 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.955 |
| dnaG | rfcS | AF_1899 | AF_2060 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Activator 1, replication factor C, 35 KD subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.497 |
| dnaG | rnhB | AF_1899 | AF_0621 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.813 |
| dnaG | top6A | AF_1899 | AF_0940 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA topoisomerase VI, subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.660 |
| dnaG | top6B | AF_1899 | AF_0652 | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA topoisomerase VI, subunit B (top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.845 |
| gyrB | AF_0465 | AF_0530 | AF_0465 | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase, subunit A (gyrA); Similar to GB:D26185 SP:P05653 GB:X02369 PID:40019 PID:467397 percent identity: 48.45; identified by sequence similarity; putative. | 0.999 |
| gyrB | dnaG | AF_0530 | AF_1899 | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.710 |
| gyrB | pcn | AF_0530 | AF_0335 | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.764 |
| gyrB | priL | AF_0530 | AF_0336 | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.446 |
