Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thi4Thiamine biosynthetic enzyme (thi1); Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (260 aa)    
Predicted Functional Partners:
AF_2208
Hydroxymethylpyrimidine phosphate kinase (thiD); Similar to GP:1842118 percent identity: 35.47; identified by sequence similarity; putative.
  
  
 0.955
thiC
Thiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.912
AF_0701
Predicted coding region AF_0701; Hypothetical protein; identified by GeneMark; putative.
       0.773
AF_0703
Predicted coding region AF_0703; Hypothetical protein; identified by GeneMark; putative.
       0.773
thiE
Thiamine phosphate pyrophosphorylase (thiE); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
     
 0.768
AF_0698
Predicted coding region AF_0698; Hypothetical protein; identified by GeneMark; putative.
       0.642
AF_0699
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58241 PID:1591518 percent identity: 32.10; identified by sequence similarity; putative.
       0.642
AF_0700
Aspartate kinase (lysC); Similar to GB:L77117 SP:Q57991 PID:1591278 percent identity: 49.13; identified by sequence similarity; putative; Belongs to the aspartokinase family.
       0.642
AF_1064
ABC transporter, ATP-binding protein, putative; Similar to PID:1653298 percent identity: 36.02; identified by sequence similarity; putative.
       0.624
purP
Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family.
 
     0.588
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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