Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AF_0704Conserved hypothetical protein; Similar to PID:1499713 GB:L77117 PID:1499713 percent identity: 35.36; identified by sequence similarity; putative. (273 aa)    
Predicted Functional Partners:
taw3
Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
 
  
 0.688
dphB
Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.671
AF_0705
Conserved hypothetical protein; Similar to GB:L77117 PID:1591957 percent identity: 38.07; identified by sequence similarity; putative; Belongs to the peptidase S16 family.
       0.625
AF_2402
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58536 PID:1591770 percent identity: 51.68; identified by sequence similarity; putative.
 
  
 0.622
taw1
Conserved hypothetical protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
 
  
 0.617
moaA
Molybdenum cofactor biosynthesis protein (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
       0.612
AF_1620
Signal-transducing histidine kinase, putative; Similar to PID:1652841 percent identity: 26.18; identified by sequence similarity; putative.
       0.595
AF_0004
RNase L inhibitor; Similar to GB:L77117 SP:Q58129 PID:1591435 percent identity: 54.45; identified by sequence similarity; putative.
 
    0.592
AF_0699
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58241 PID:1591518 percent identity: 32.10; identified by sequence similarity; putative.
 
     0.568
AF_0701
Predicted coding region AF_0701; Hypothetical protein; identified by GeneMark; putative.
       0.563
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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