Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AF_0711Thioredoxin (trx-1); Similar to SP:P06544 GB:M14736 PID:142118 percent identity: 28.36; identified by sequence similarity; putative. (119 aa)    
Predicted Functional Partners:
AF_0270
Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 0.851
AF_2220
Predicted coding region AF_2220; Hypothetical protein; identified by GeneMark; putative.
  
 0.837
AF_0712
Conserved hypothetical protein; Similar to GP:1226253 percent identity: 36.54; identified by sequence similarity; putative.
   
 
 0.802
AF_1554
Thioredoxin reductase (trxB); Similar to PID:1171125 SP:P52213 percent identity: 45.21; identified by sequence similarity; putative.
  
 
 0.739
ppsA
Phosphoenolpyruvate synthase (ppsA); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
       0.549
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.544
AF_1664
Ribonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
   
 0.534
AF_2192
Cytochrome C-type biogenesis protein (nrfE); Similar to GP:1790511 percent identity: 36.13; identified by sequence similarity; putative.
  
  
 0.534
AF_1980
Heme exporter protein C (helC); Similar to SP:P29961 GB:X63462 PID:46026 percent identity: 29.02; identified by sequence similarity; putative.
  
  
 0.532
AF_0142
Cytochrome C oxidase, subunit II, putative; Similar to GB:L09121 PID:155085 SP:P98052 percent identity: 38.04; identified by sequence similarity; putative.
   
 
 0.521
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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