Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
AF_0713Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA-1); Similar to GB:L77117 SP:Q58114 PID:1591418 percent identity: 37.50; identified by sequence similarity; putative; Belongs to the HisA/HisF family. (223 aa)    
Predicted Functional Partners:
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA-2); Similar to GB:L77117 SP:Q58927 PID:1592163 percent identity: 42.24; identified by sequence similarity; putative.
     
 0.924
hisF
Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
     
 0.920
hisI
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
     
  0.900
hisH
Imidazoleglycerol-phosphate synthase, subunit H (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
     
  0.900
mfnB
Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.883
AF_1930
Tungsten formylmethanofuran dehydrogenase, subunit A (fwdA); Similar to GB:L77117 PID:1591795 percent identity: 48.91; identified by sequence similarity; putative.
 
   
 0.774
AF_0572
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57900 PID:1499252 percent identity: 34.36; identified by sequence similarity; putative.
 
     0.756
AF_0479
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58250 PID:1591527 percent identity: 41.38; identified by sequence similarity; putative.
 
     0.754
AF_2257
Conserved hypothetical protein; Similar to GB:L77117 SP:Q58186 PID:1499596 percent identity: 30.64; identified by sequence similarity; putative.
 
     0.744
AF_1061
Conserved hypothetical protein; Similar to GB:L77117 PID:1591504 percent identity: 42.64; identified by sequence similarity; putative.
 
     0.741
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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