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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrDDihydroorotase dehydrogenase (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (299 aa)    
Predicted Functional Partners:
pyrK
Cytochrome-c3 hydrogenase, subunit gamma; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 0.999
pyrE
Orotate phosphoribosyl transferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.999
pyrC
Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.999
pyrB
Aspartate carbamoyltransferase, catalytic subunit (pyrB); Similar to GB:L77117 PID:1500476 percent identity: 60.74; identified by sequence similarity; putative.
 
  
 0.996
pyrF
Conserved hypothetical protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.996
carB
Carbamoyl-phosphate synthase, large (or ammonia) subunit (carB); Similar to PID:1001613 PID:1001668 percent identity: 65.08; identified by sequence similarity; putative.
  
 
 0.996
carA
Carbamoyl-phosphate synthase, small (or glutamine) subunit (carA); Similar to GB:L77117 SP:Q58425 PID:1591677 percent identity: 55.17; identified by sequence similarity; putative; Belongs to the CarA family.
 
  
 0.991
ribH
Riboflavin synthase, subunit beta (ribE); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.948
AF_0386
Orotate phosphoribosyl transferase, putative; Similar to GB:L77117 PID:1500547 percent identity: 39.04; identified by sequence similarity; putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.926
purF
Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
  
 0.764
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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