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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glyASerine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (451 aa)    
Predicted Functional Partners:
AF_1811
Inosine monophosphate cyclohydrolase; Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 38.27; identified by sequence similarity; putative.
  
 0.998
AF_2047
Thymidylate synthase, putative; Similar to GB:M19653 SP:P00469 PID:149601 percent identity: 33.14; identified by sequence similarity; putative.
 
 
 0.972
AF_2138
Phosphoserine phosphatase (serB); Similar to GB:L77117 PID:1592204 percent identity: 50.71; identified by sequence similarity; putative; Belongs to the HAD-like hydrolase superfamily. SerB family.
  
 0.966
AF_0274
Sarcosine oxidase, subunit beta (soxB); Similar to SP:P40875 PID:927589 percent identity: 26.45; identified by sequence similarity; putative.
  
 
 0.959
trpA
Tryptophan synthase, subunit alpha (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 
 0.947
trpB1
Tryptophan synthase, subunit beta (trpB-2); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
    
 0.944
serA
Phosphoglycerate dehydrogenase (serA); Similar to GB:L77117 PID:1591676 percent identity: 48.77; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.940
purB
Adenylosuccinate lyase (purB); Similar to GB:L77117 PID:1591600 percent identity: 52.27; identified by sequence similarity; putative.
  
  
 0.936
purD
Phosphoribosylamine--glycine ligase (purD); Similar to GB:L42023 SP:P43845 PID:1005977 PID:1220991 PID:1205135 percent identity: 40.90; identified by sequence similarity; putative.
  
 
 0.935
purA
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
  
 0.930
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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