close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhL-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. (294 aa)    
Predicted Functional Partners:
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
  
 0.999
icd
Isocitrate dehydrogenase, NADP (icd); Similar to GB:J02799 SP:P08200 PID:146432 GB:U00096 PID:1651560 percent identity: 57.18; identified by sequence similarity; putative; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.992
AF_1098
Fumarase (fum-1); Similar to GB:L77117 SP:Q58034 PID:1591328 percent identity: 49.13; identified by sequence similarity; putative.
  
 
 0.990
AF_1099
Fumarase (fum-2); Similar to GB:L77117 SP:Q58690 PID:1591932 percent identity: 53.38; identified by sequence similarity; putative.
  
 
 0.989
AF_1727
Malate oxidoreductase (mae); Similar to GP:1006839 percent identity: 52.30; identified by sequence similarity; putative.
  
 0.970
AF_2129
Aspartate aminotransferase (aspB-2); Similar to PID:1146246 SP:P53001 GB:AL009126 percent identity: 45.38; identified by sequence similarity; putative.
  
 0.959
AF_2366
Aspartate aminotransferase (aspB-1); Similar to GB:L77117 SP:Q60317 PID:1592252 percent identity: 42.31; identified by sequence similarity; putative.
  
 0.959
ppcA
Predicted coding region AF_1486; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
     
 0.955
pycA
Biotin carboxylase (acc); Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
    
 0.951
rpl4
LSU ribosomal protein L4P (rpl4P); One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.945
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.