node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AF_0891 | fno | AF_0891 | AF_0892 | Predicted coding region AF_0891; Hypothetical protein; identified by GeneMark; putative. | Conserved hypothetical protein; Catalyzes the reversible reduction of NADP(+) by F420H(2). In this reaction the proS hydrogen at C5 of F420 is transferred into the proS position at C4 of NADPH; Belongs to the F420-dependent NADP reductase family. | 0.495 |
carB | cofG | AF_1274 | AF_0797 | Carbamoyl-phosphate synthase, large (or ammonia) subunit (carB); Similar to PID:1001613 PID:1001668 percent identity: 65.08; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.541 |
carB | fno | AF_1274 | AF_0892 | Carbamoyl-phosphate synthase, large (or ammonia) subunit (carB); Similar to PID:1001613 PID:1001668 percent identity: 65.08; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the reversible reduction of NADP(+) by F420H(2). In this reaction the proS hydrogen at C5 of F420 is transferred into the proS position at C4 of NADPH; Belongs to the F420-dependent NADP reductase family. | 0.459 |
cofC | cofD | AF_2061 | AF_0917 | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.997 |
cofC | cofE | AF_2061 | AF_2256 | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | 0.978 |
cofC | cofG | AF_2061 | AF_0797 | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.947 |
cofC | fno | AF_2061 | AF_0892 | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | Conserved hypothetical protein; Catalyzes the reversible reduction of NADP(+) by F420H(2). In this reaction the proS hydrogen at C5 of F420 is transferred into the proS position at C4 of NADPH; Belongs to the F420-dependent NADP reductase family. | 0.717 |
cofC | mer | AF_2061 | AF_1066 | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | N5,N10-methylenetetrahydromethanopterin reductase (mer-1); Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family. | 0.695 |
cofD | cofC | AF_0917 | AF_2061 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.997 |
cofD | cofE | AF_0917 | AF_2256 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | 0.998 |
cofD | cofG | AF_0917 | AF_0797 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.995 |
cofD | fno | AF_0917 | AF_0892 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | Conserved hypothetical protein; Catalyzes the reversible reduction of NADP(+) by F420H(2). In this reaction the proS hydrogen at C5 of F420 is transferred into the proS position at C4 of NADPH; Belongs to the F420-dependent NADP reductase family. | 0.766 |
cofD | gap | AF_0917 | AF_1732 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | Glyceraldehyde 3-phosphate dehydrogenase (gap); Similar to SP:P10618 PID:149792 percent identity: 56.59; identified by sequence similarity; putative. | 0.600 |
cofD | mer | AF_0917 | AF_1066 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | N5,N10-methylenetetrahydromethanopterin reductase (mer-1); Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family. | 0.753 |
cofD | pgk | AF_0917 | AF_1146 | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 3-phosphoglycerate kinase (pgk); Similar to GB:L77117 SP:Q58058 PID:1592299 percent identity: 48.77; identified by sequence similarity; putative. | 0.508 |
cofE | cofC | AF_2256 | AF_2061 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.978 |
cofE | cofD | AF_2256 | AF_0917 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.998 |
cofE | cofG | AF_2256 | AF_0797 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.949 |
cofE | fno | AF_2256 | AF_0892 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | Conserved hypothetical protein; Catalyzes the reversible reduction of NADP(+) by F420H(2). In this reaction the proS hydrogen at C5 of F420 is transferred into the proS position at C4 of NADPH; Belongs to the F420-dependent NADP reductase family. | 0.775 |
cofE | mer | AF_2256 | AF_1066 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus. | N5,N10-methylenetetrahydromethanopterin reductase (mer-1); Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family. | 0.819 |