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cofD protein (Archaeoglobus fulgidus) - STRING interaction network
"cofD" - 2-phospho-L-lactate transferase in Archaeoglobus fulgidus
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Known Interactions
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Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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cofD2-phospho-L-lactate transferase; Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5’)guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP (296 aa)    
Predicted Functional Partners:
cofE
Coenzyme F420-L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0- glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus (249 aa)
 
 
  0.999
cofC
2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5’-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family (206 aa)
 
   
  0.998
cofH
FO synthase subunit 2; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (338 aa)
 
   
  0.980
cofG
FO synthase subunit 1; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (324 aa)
 
   
  0.968
mtd
F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MTD family (273 aa)
   
   
    0.919
AF_0918
Pyruvate formate-lyase activating enzyme (Act-2); Similar to GB-L77117 SP-Q58214 PID-1499627 percent identity- 42.65; identified by sequence similarity; putative (283 aa)
              0.848
glyS
Glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly) (570 aa)
              0.845
AF_0919
Phosphoesterase; Similar to GB-L77117 SP-Q58346 PID-1499771 percent identity- 40.97; identified by sequence similarity; putative (151 aa)
              0.747
mqnC
Cyclic dehypoxanthine futalosine synthase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) (355 aa)
 
     
  0.736
aspS
Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps- L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn) (430 aa)
              0.713
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus DSM4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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