| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AF_0817 | fen | AF_0817 | AF_0264 | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.908 |
| AF_0817 | mre11 | AF_0817 | AF_1031 | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.603 |
| AF_0817 | rad50 | AF_0817 | AF_1032 | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | Purine NTPase, putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.558 |
| AF_0817 | radA | AF_0817 | AF_0993 | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | DNA repair protein RAD51 (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.792 |
| AF_0817 | radB | AF_0817 | AF_2096 | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | DNA repair protein REC; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.792 |
| AF_0817 | top6A | AF_0817 | AF_0940 | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | DNA topoisomerase VI, subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.647 |
| AF_2418 | fen | AF_2418 | AF_0264 | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.928 |
| AF_2418 | mre11 | AF_2418 | AF_1031 | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.658 |
| AF_2418 | rad50 | AF_2418 | AF_1032 | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | Purine NTPase, putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.558 |
| AF_2418 | radA | AF_2418 | AF_0993 | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | DNA repair protein RAD51 (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.792 |
| AF_2418 | radB | AF_2418 | AF_2096 | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | DNA repair protein REC; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.792 |
| AF_2418 | top6A | AF_2418 | AF_0940 | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | DNA topoisomerase VI, subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.647 |
| fen | AF_0817 | AF_0264 | AF_0817 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Conserved hypothetical protein; Similar to GB:L77117 PID:1500447 percent identity: 42.53; identified by sequence similarity; putative. | 0.908 |
| fen | AF_2418 | AF_0264 | AF_2418 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA repair protein, putative; Similar to GB:U64315 SP:Q92889 PID:1524411 PID:1905924 percent identity: 28.86; identified by sequence similarity; putative. | 0.928 |
| fen | gyrB | AF_0264 | AF_0530 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.715 |
| fen | mre11 | AF_0264 | AF_1031 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.988 |
| fen | rad50 | AF_0264 | AF_1032 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Purine NTPase, putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.977 |
| fen | radA | AF_0264 | AF_0993 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA repair protein RAD51 (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.955 |
| fen | radB | AF_0264 | AF_2096 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA repair protein REC; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.966 |
| fen | top6A | AF_0264 | AF_0940 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA topoisomerase VI, subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.588 |