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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cimA2-isopropylmalate synthase (leuA-1); Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (489 aa)    
Predicted Functional Partners:
leuC1
Aconitase (acn); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.984
leuD2
3-isopropylmalate dehydratase, small subunit (leuD-2); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.981
leuC2
3-isopropylmalate dehydratase, large subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.981
leuD1
3-isopropylmalate dehydratase, small subunit (leuD-1); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.980
ilvH
Acetolactate synthase, small subunit (ilvN); Similar to GB:L77117 SP:Q57625 PID:1590918 percent identity: 60.38; identified by sequence similarity; putative; Belongs to the acetolactate synthase small subunit family.
  
 
 0.974
ilvE
Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.964
AF_1720
Acetolactate synthase, large subunit (ilvB-1); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 57.48; identified by sequence similarity; putative.
 
 
 0.958
AF_1780
Acetolactate synthase, large subunit (ilvB-2); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 32.06; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
  
 
 0.952
AF_2015
Acetolactate synthase, large subunit (ilvB-3); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 34.07; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
  
 
 0.952
AF_2100
Acetolactate synthase, large subunit (ilvB-4); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 38.42; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
  
 
 0.952
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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