Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AF_0975acetyl-CoA synthetase (acs-4); Similar to GB:M63968 SP:P27095 PID:150032 percent identity: 42.26; identified by sequence similarity; putative. (642 aa)    
Predicted Functional Partners:
AF_1340
Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative.
  
 0.963
AF_1938
Conserved hypothetical protein; Catalyzes the reversible conversion of a variety of acids to the corresponding acyl-CoA esters. Shows the highest activity with the aryl acids, indoleacetate and phenylacetate, as compared to acetate. In the reverse direction, phenylacetyl-CoA is the best substrate. Seems to be involved primarily in the degradation of aryl-CoA esters to the corresponding acids. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters. In the C-terminal section; belongs to the acetate CoA ligase alpha subunit family.
    
 0.947
cdhE
acetyl-CoA decarbonylase/synthase, subunit gamma (cdhE); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
   
 
 0.946
korB
2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB); Similar to GB:L77117 PID:1591241 percent identity: 51.38; identified by sequence similarity; putative.
  
 
 0.946
AF_1699
Pyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 50.84; identified by sequence similarity; putative.
  
 
 0.946
AF_1211
Conserved hypothetical protein; Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as propionyl-CoA and butyryl-CoA, but not phenylacetyl-CoA. Seems to be involved primarily in the conversion of acetyl-CoA to acetate. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters; In the C-terminal section; belongs to the acetate CoA ligase beta subunit family.
    
 0.945
leuA
2-isopropylmalate synthase (leuA-2); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).
  
 
 0.921
AF_1028
3-ketoacyl-CoA thiolase (fadA-1); Similar to GP:1742272 percent identity: 38.83; identified by sequence similarity; putative.
  
 
 0.920
AF_1702
Pyruvate ferredoxin oxidoreductase, subunit beta (porB); Similar to GB:L77117 PID:1590994 percent identity: 50.70; identified by sequence similarity; putative.
  
 
 0.918
AF_2052
2-ketoisovalerate ferredoxin oxidoreductase, subunit beta (vorB); Similar to PID:1197361 percent identity: 42.65; identified by sequence similarity; putative.
  
 
 0.918
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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