Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadENH(3)-dependent NAD+ synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (247 aa)    
Predicted Functional Partners:
AF_1488
Conserved hypothetical protein; Similar to GB:L77117 SP:Q57961 PID:1591245 percent identity: 44.64; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family.
 
  
 0.947
AF_2315
Conserved hypothetical protein; Similar to GP:1591245 percent identity: 57.40; identified by sequence similarity; putative.
 
  
 0.945
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.937
AF_0115
Conserved hypothetical protein; Similar to GB:X52543 PID:46506 SP:P55177 percent identity: 31.85; identified by sequence similarity; putative.
   
 0.935
cobB2
Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
    
 0.924
cobB1
Transcriptional regulatory protein, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
    
 0.924
AF_0999
Predicted coding region AF_0999; Hypothetical protein; identified by GeneMark; putative.
       0.773
AF_0821
Conserved hypothetical protein; Similar to SP:Q10641 PID:1340096 percent identity: 34.33; identified by sequence similarity; putative.
 
  
 0.736
argF
Ornithine carbamoyltransferase (argF); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
     0.661
AF_1770
Dipeptide ABC transporter, ATP-binding protein (dppD); Similar to SP:P37314 PID:349228 PID:466680 GB:U00096 PID:1789963 percent identity: 47.77; identified by sequence similarity; putative.
       0.624
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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