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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AF_1107Conserved hypothetical protein; Similar to PID:1652585 percent identity: 43.41; identified by sequence similarity; putative. (146 aa)    
Predicted Functional Partners:
dut
Deoxycytidine triphosphate deaminase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
       0.661
eno
Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
   0.632
AF_0364
ATP-dependent protease La (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
    
   0.631
AF_1109
Predicted coding region AF_1109; Hypothetical protein; identified by GeneMark; putative.
       0.608
AF_1110
Predicted coding region AF_1110; Hypothetical protein; identified by GeneMark; putative.
       0.608
pan
26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
  
    0.562
AF_0673
Mercuric resistance operon regulatory protein (merR); Similar to SP:P22853 PID:1129093 percent identity: 33.04; identified by sequence similarity; putative.
     
 0.496
AF_0287
Electron transfer flavoprotein, subunit alpha (etfA); Similar to PID:596026 SP:P53571 percent identity: 39.75; identified by sequence similarity; putative.
 
     0.455
AF_1111
Predicted coding region AF_1111; Hypothetical protein; identified by GeneMark; putative.
       0.446
AF_0286
Electron transfer flavoprotein, subunit beta (etfB); Similar to GP:1903329 percent identity: 38.80; identified by sequence similarity; putative.
 
     0.438
Your Current Organism:
Archaeoglobus fulgidus
NCBI taxonomy Id: 224325
Other names: A. fulgidus DSM 4304, Archaeoglobus fulgidus DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus strain DSM 4304
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